LYMPHOID NEOPLASIA Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation
نویسندگان
چکیده
1Epigenetic and Telomeric Regulations, Lyon Sud Medicine Faculty, Lyon-1 University, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5239, Pierre Bénite, France; 2Laboratory of Biology and Pathology of Genomes, University of Nice, Medicine Faculty, UMR 6267 CNRS U998 Inserm, Nice, France; 3Inserm, U823, Institut Albert Bonniot, Grenoble, France; 4Université Joseph Fourier-Grenoble I, Grenoble, France; 5Laboratoire d’Hématologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France; 6Hospices Civils de Lyon, Lyon-1 University, CNRS UMR 5239, Pierre Bénite, France; 7Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Unité Médicale d’Oncologie Moléculaire et Transfert, Service de Biochimie, Pierre Bénite, France; and 8Department of Medical Genetics, Centre Hospitalier Universitaire (CHU) de Nice, Archet 2 Hospital, Nice, France
منابع مشابه
Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation.
Cells of B-cell chronic lymphocytic leukemia (B-CLL) are characterized by short telomeres despite a low proliferative index. Because telomere length has been reported to be a valuable prognosis criteria, there is a great interest in a deep understanding of the origin and consequences of telomere dysfunction in this pathology. Cases of chromosome fusion involving extremely short telomeres have b...
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تاریخ انتشار 2011